BRL 15572

BRL-15572 is a serotonin receptor subtype 5-HT1D antagonist with a pKi of 7.9. BRL15572 displays 60-fold selectivity over h5-HT1B, and exhibiting litt...

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YO 01027 (Dibenzazepine, DBZ)

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of amyloid precursor protein...

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Vilazodone

Vilazodone acts as a serotonin reuptake inhibitor (IC50 = 0.5 nM) and 5-HT1A receptor partial agonist (IC50 = 0.2 nM; IA = ~60-70%). Vilazodone was ap...

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Fesoterodine fumarate (Toviaz)

Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a ...

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Zaleplon

Zaleplon is an agonist at the GABA A ɣ 1 subunit.Zaleplon is a sedative/hypnotic, mainly used for insomnia. [1][2] Reference: [1] J Clin. Ps...

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LY 310762

LY310762 is a 5-HT1D serotonin receptor antagonist for the guinea pig 5-HT1D receptor with a Ki of median 0.2 μM. [1][2] Reference: ...

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Semagacestat (LY 450139)

Semagacestat (LY450139) is a γ-secretase blocker of Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. ...

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E 2012

E 2012 is γ-secretase inhibitor. Reference:
Chemical Information Molecula...

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MK 0752

MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells. MK0752 inhibi...

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RO 4929097

RO4929097 is an orally bioavailable γ secretase (GS) inhibitor with IC50 of 4 nM. RO-4929097 binds to GS and blocks activation of Notch receptor...

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DAPT (GSX-IX)

DAPT (GSX-IX) is a novel inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50...

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LY 411575

LY-411575 is a potent γ-secretase inhibitor as assessed by inhibition of Aβ production (IC50, 0.078 and 0.082 nM in membrane- and cell-base...

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BMS 708163

BMS-708163 (avagacestat) is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. ...

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Solifenacin (YM 905)

Solifenacin (YM905) is a competitive muscarinic acetylcholine receptor antagonist. The binding of acetylcholine to these receptors, particularly the M...

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Tropisetron

Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. ...

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Rivastigmine tartrate (Exelon)

Rivastigmine tartrate (Exelon) is a dual cholinesterase inhibitor (ChEI). It inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE...

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