Apoptosis
Aurora Kinase
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Product name : RI-1
Item : c2373
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 415713-60-9
Molecular Weight : 361.61
Formula : C₁₄H₁₁Cl₃N₂O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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| Details: |
Description of:RI-1
RI-1(cas:415713-60-9)is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM. IC50 Value: 5-30 μM Target: RAD51 in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. Quality control data: Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS. Product will be shipped with supporting analytical data. REFERENCES |
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