Favorite  |  Set Home
Product name : SAR131675
Item : c2304
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 1092539-44-0 or 1433953-83-3
Molecular Weight : 358.398
Formula : C18H22N4O4
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
 Enlarge Image                   Back
             [Next Product]→


Details:
Description of:SAR131675
SAR131675(CAS:1092539-44-0 or 1433953-83-3 ) is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. AR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it is moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 inhibits VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nM, respectively. SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. SSAR131675 has no antiproliferative activity on a panel of 30 tumors and primary cells, further showing its high specificity and indicating that SAR131675 is not a cytotoxic or cytostatic agent.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 

REFERENCES

[1]. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49.

Related Products :
BFH772
BFH772
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
SU5408
SU5408
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
NVP-ACC789 (Synonyms: ACC-789; ZK202650)
NVP-ACC789 (Synonyms: ACC-789; ZK202650)
Price: 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995