Apoptosis
Telomerase
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Product name : LY 294002 (NSC 697286, SF 1101)
Item : cc58
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 154447-36-6
Molecular Weight : 307.34
Formula : C₁₉H₁₇NO₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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LY 294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4µM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. [1][2]
Reference:
[1] J Biol. Chem. 1994, 7, 5241-5248.
[2] Purinergic Signal 2005, 1, 389-394.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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