Product name : PP 121
Item : cc496
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1092788-83-4
Molecular Weight : 319.36
Formula : C₁₇H₁₇N₇
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). PP-121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP 121 blocks the proliferation of tumor cells by direct inhibition of PI3-K, mTOR, Src and the VEGF receptor. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1]
Reference:
[1] Nature Chem. Biol. 2008, 4, 691-699.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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