Apoptosis
Telomerase
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Product name : OSI 027
Item : cc501
Price : 200mg, $1250;500mg, $2150; 1g $3050; 2g, $4450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 936890-98-1
Molecular Weight : 406.44
Formula : C₂₁H₂₂N₆O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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OSI 027 is an orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. [1][2]
Reference:
[1] Proc. Natl. Acad. Sci. USA. 2010, 107, 12469-12474.
[2] Mol. Cancer Ther. 2011, 10, 1394-13406.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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