Apoptosis
Telomerase
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Product name : WYE 125132 (WYE 132)
Item : cc15
Price : 200mg, $1250;500mg, $2150; 1g $3050; 2g, $4450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1144068-46-1
Molecular Weight : 519.6
Formula : C₂₇H₃₃N₇O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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WYE-125132 (WYE-132), is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19 ± 0.07 nmol/L; >5,000-fold selective versus PI3Ks). WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells. [1][2]
Reference:
[1] Cancer Res. 2010, 70, 621.
[2] J Biol. Chem. 2010, 285, 15380-15392.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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