Apoptosis
Telomerase
|
Product name : TWS 119
Item : cc510
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 601514-19-6
Molecular Weight : 318.33
Formula : C₁₈H₁₄N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 |
| Details: | |||||||||||||||||||||||||
TWS 119 is a cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). TWS119 binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. It is shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM). [1][2]
Reference:
[1] Proc. Natl. Acad. Sci. USA. 2003, 100, 7632-7637.
[2] Biochem. Biophys. Res. Commun. 2010, 391, 1049-1055.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
|
| Related Products : |
|
|
|
|
||||||||
|
|
|
|
Chinese
Deutsch
Espanol
Francais
Italiano
Portugues
Japanese
Korean
Arabic
Russian