Apoptosis
EGFR
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Product name : Tofacitinib (CP-690550)
Item : cc396
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 477600-75-2
Molecular Weight : 312.37
Formula : C₁₆H₂₀N₆O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Tofacitinib (Tasocitinib, CP-690550) is a novel, small molecule inhibitor of JAK3 with an IC50 with 1 nM, and exhibits rather indiscriminate activity towards JAK1 (IC50 = 112 nM) and JAK2 (IC50 = 20 nM). CP 690550 is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3. [1][2]
Reference:
[1] Science 2003, 302, 875-878.
[2] Eur. J Pharmacol. 2008, 582, 154-161.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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