Product name : SU5402
Item : cc522
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 215543-92-3
Molecular Weight : 296.32
Formula : C₁₇H₁₆N₂O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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SU 5402 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also SU-5402 inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. SU5402 does not inhibit the kinase activity of the EGF receptor.[1][2]
Reference:
[1] J Med. Chem. 1999, 42, 5120-5130.
[2] Nature 2005, 435, 172-177.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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