Apoptosis
Btk
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Product name : Amuvatinib (MP 470)
Item : cc525
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 850879-09-3
Molecular Weight : 447.51
Formula : C₂₃H₂₁N₅O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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MP-470 (Amuvatinib) is a potent and multi-targeted tyrosine kinase inhibitor that inhibits kinases including c-Kit and PDGFα, as well as their mutants, with IC50 of 10 nM to 31 μM. Amuvatinib binds to mutant forms of the stem cell factor receptor (c-Kit; SCFR), inhibiting clinically relevant mutants of this receptor tyrosine kinase that may be associated with resistance to therapy. In addition, MP470 inhibits activities of other receptor tyrosine kinases, such as c-Met, Ret oncoprotein, and mutant forms of Flt3 and PDGFR alpha, which are frequently dysregulated in variety of tumors. This agent also suppresses the induction of DNA repair protein Rad51, thereby potentiating the activities of DNA damage-inducing agents. Mutant forms of c-Kit are often associated with tumor chemoresistance. [1][2]
Reference:
[1] Cancer Chemther. Pharmacol. 2011, 67, 809-812.
[2] Oncogene 2007, 26, 3909-3919.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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