Apoptosis
Btk
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Product name : BAY 61-3606
Item : cc526
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 648903-57-5(2HCl); 732983-37-8(Free Base)
Molecular Weight : 463.32
Formula : C₂₀H₂₀Cl₂N₆O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||
Syk Inhibitor IV, BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. BAY 61-3606 has been shown to inhibit Syk-mediated cellular functions such as inhibition of high glucose-tyrosine phosphorylation of I kappa B α and p65 nuclear translocation. In mast cells BAY 61-3606 has inhibited cytokine synthesis, lipid mediation and degranulation. In addition, monocyte and eosinophil activation by B cells and Fc receptors were suppressed by BAY 61-3606. [1][2]
Reference:
[1] J Pharm. Exp. Ther. 2003, 306, 1174-1181.
[2] Am. J Physiol. Renal Physiol. 2008, 294, F1065-F1075.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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