Product name : BMS 536924
Item : cc534
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 468740-43-4
Molecular Weight : 479.96
Formula : C₂₅H₂₆ClN₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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BMS-535924 is a potent inhibitor of the IGF-1 receptor in vitro (IC50 = 100 nM).BMS536924 has been shown to inhibit the catalytic activityof IGF-1R and its down stream signaling components such as Aktand MAPK in cells; it also inhibits proliferation in a widevariety of human cancer cell lines including, colon, breast,lung, pancreas, prostate, sarcoma and multiple myeloma. In vivo,BMS-536924 inhibits tumor growth in an IGF-1R-dependent tumormodel (IGF-1R Sal) as well as in a broad range of human tumorxenografts. [1][2]
Reference:
[1] J Med. Chem. 2008, 51, 5897-5900.
[2] Br. J Pharmacol. 2007, 64, 292-303.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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