Apoptosis
Btk
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Product name : Crenolanib (CP 868596)
Item : cc84
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 670220-88-9
Molecular Weight : 443.54
Formula : C₂₆H₂₉N₅O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Crenolanib (CP-868596) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, respectively. In addition,Crenolanib (CP868596) inhibits the activity of PDGFRα D842V kinase with an IC50 of 1 nM. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. [1][2]
Reference:
[1] Br. J Cancer 2010, 103, 1554-1561.
[2] J Clin. Oncol. 2009, 27, 5262-5269.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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