Product name : WZ 8040
Item : cc536
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1214265-57-2
Molecular Weight : 481.01
Formula : C₂₄H₂₅ClN₆OS
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM). WZ-8040 is an irreversiblely inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ 8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro. [1]
Reference:
[1] Nature 2009, 462, 1070-1074.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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