Apoptosis
Btk
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Product name : Dacomitinib (PF 299804)
Item : cc194
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1110813-31-4
Molecular Weight : 469.94
Formula : C₂₄H₂₅ClFN₅O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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PF299804 (Dacomitinib) is a potent, irreversible pan-ERBB inhibitor against EGFR (ERBB1), ERBB2 and ERBB4 with IC50 with 6 nM, 45.7 nM and 73.7 nM, respectively.PF-299804 specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. [1][2]
Reference:
[1] Clin. Cancer Res. 2011, 17, 1131-1139.
[2] Cancer Res. 67, 11924-11932.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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