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Products > Receptor Tyrosine Kinase > c-Kit > Masitinib (AB 1010)
Product name : Masitinib (AB 1010)
Item : cc179
Price : 1g, $650;2g, $1050; 5g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 790299-79-5
Molecular Weight : 498.64
Formula : C₂₈H₃₀N₆OS
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
AB1010 (Masitinib) is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyrosine phosphorylation and the recombinant human wild-type KIT. AB 1010 selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).  [1][2]
 
Reference:
[1] Aleheimers Res. Ther. 2011, 3, 16.
[2] Eur. J Haematol. 2012, 89, 47-52.
 
 
Chemical Information
Molecular Weight (WM):
498.64
Formula:
C28H30N6OS
CAS No:
790299-79-5
Purity:
≥ 98%
Synonyms:
AB-1010
 
DMSO ≥ 100 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 4 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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