Apoptosis
Btk
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Product name : Dovitinib (TKI-258)
Item : cc257
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 405169-16-6
Molecular Weight : 392.43
Formula : C₂₁H₂₁FN₆O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Dovitinib (TKI258, CHIR258) is a novel multitargeted growth factor receptor kinase inhibitor of FLT3, c-KIT, FGFR1/3, VEGFR1/2/3 with IC50 of 1 nM, 2 nM, 8 nM, 9 nM, 10 nM, 13 nM and 8 nM, respectively. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types. [1][2]
Reference:
[1] Blood 2005, 105, 2941-2948.
[2] Clin. Cancer Res. 2005, 11, 3633-3641.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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