Product name : JNJ-38877605
Item : cc51
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 943540-75-8
Molecular Weight : 377.35
Formula : C₁₉H₁₃F₂N₇
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
|
Details: | |||||||||||||||||||||||||
JNJ-38877605 is an ATP-competitive inhibitor for the catalytic activity of c-Met with IC50 of 4 nM. JNJ38877605 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. [1][2]
Reference:
[1] Caner Res. 2010, 70, 7580-7590.
[2] J Natl. Cancer Inst. 2011, 103, 645-661.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
Related Products : |
|
|
|
|
||||||||
|
|
|
|