Tanespimycin/17-AAG/NSC330507/NSC-330507/NSC 330507/CP127374/CP-127374/CP 127374/75747-14-7/911710-03-7/acesobio supply

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Product name : Tanespimycin (17-AAG, NSC330507)

Item : cc545

Price : 1g, $650;2g, $1050; 5g $1650

contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.

CAS : 75747-14-7

Molecular Weight : 585.69

Formula : C₃₁H₄₃N₃O₈

Storage : at -20°C

Additional information : We offer significant discount for bulky quantity order

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Details:

17-AAG (Tanespimycin) is a potent heat shock protein 90 (Hsp90) inhibitor with IC50 of 5 nM.Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. ^[1][2]

Reference:

[1] Nature 2003, 425, 407-410.

[2] Clin. Cancer Res. 2002, 8, 986-993.

Chemical Information

Molecular Weight (WM):	585.69
Formula:	C₃₁H₄₃N₃O₈
CAS No:	75747-14-7, 911710-03-7 (HCl)
Purity:	≥ 98%
Synonyms:	NSC 330507, CP 127374, CP-127374
	DMSO ≥ 20 mg/mL
Solubility (25℃)	Water < 1 mg/mL
	Ethanol ≥ 5 mg/mL
	2 years -20℃ Powder
Stability:	2 weeks -4℃ in DMSO
	2 months -80℃ in DMSO