VX222/VX-222/VX 222/VCH222/VCH 222/VCH-222/1026785-55-6/1026785-59-0/acesobio supply

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Product name : VX 222 (VCH 222)

Item : cc546

Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995

contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.

CAS : 1026785-59-0

Molecular Weight : 445.61

Formula : C₂₅H₃₅NO₄S

Storage : at -20°C

Additional information : We offer significant discount for bulky quantity order

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Details:

VX-222 (VCH-222) is a novel, potent and selective inhibitor of non-nucleoside polymerase of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, with an IC50 range of 0.94-1.2 μM. VX-222 binds to the thumb II allosteric pocket of the HCV RNA-dependent RNA polymerase. VX 222 exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 μM, respectively. VX222 selectively inhibits the replication of subgenomic HCV genotype 1a and 1b with an EC50 of 22.3 and 11.2 nM, respectively. ^[1][2]

Reference:

[1] J Hepatol 2009, 50(suppl 1), S340.

[2] Antimicrob. Agents Chemother. 2012, 56, 830-837.

Chemical Information

Molecular Weight (WM):	445.61
Formula:	C₂₅H₃₅NO₄S
CAS No:	1026785-55-6, 1026785-59-0
Purity:	≥ 98%
Synonyms:	VCH222, VCH 222
	DMSO ≥ 89 mg/mL
Solubility (25℃)	Water < 1 mg/mL
	Ethanol ≥ 89 mg/mL
	2 years -20℃ Powder
Stability:	2 weeks -4℃ in DMSO
	2 months -80℃ in DMSO