Product name : DMXAA (ASA404)
Item : cc419
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 117570-53-3
Molecular Weight : 282.29
Formula : C₁₇H₁₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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DMXAA (ASA404) is a competitive inhibitor of DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC 1.6.99.2) with Ki of 20 μM and IC50 of 62.5 μM, respectively. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. [1][2]
Reference:
[1] Biochem. Pharmcol. 1999, 58, 303-310.
[2] J Leukoc. Biol. 2011, 89, 351-357.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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