Apoptosis
Btk
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Product name : Brivanib alaninate (BMS-582664)
Item : cc420
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 649735-63-7
Molecular Weight : 441.46
Formula : C₂₂H₂₄FN₅O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Brivanib alaninate (BMS-582664) is VEGFR-PDGFR inhibitor. Brivanib alaninate is a multiple inhibitor of VEGFR( IC50 of VEGFR-2(25 nM), VEGFR-1 (380nM), VEGFR-3 (10 nM)); FGFR (FGFR-1 (IC50=148 nM), FGFR-2 (IC50 =125 nM), and FGFR-3 (IC50 = 68 nM))tyrosine kinases. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. [1][2]
Reference:
[1] Clin. Cancer Res. 2008, 14, 6146-6153.
[2] J Med. Chem. 2008, 51, 1976-1980.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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