Apoptosis
MNK
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Product name : VX 702
Item : cc421
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 745833-23-2
Molecular Weight : 404.32
Formula : C₁₉H₁₂F₄N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM). Pre-incubation of platelets with VX 702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen. VX-702 shows no effect on platelet aggregation induced by any of the p38 MAPK agonists in the presence or absence of anti-platelet therapies. VX702 inhibits the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/mL, respectively) in a dose-dependent manner. [1][2]
Reference:
[1] Thromb. Haemost. 2004, 92, 1387-1393.
[2] Curr. Med. Chem. 2005, 12, 2979-2994.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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