Product name : Rucaparib (AG 014699, PF 01367338)
Item : cc55
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 459868-92-9
Molecular Weight : 421.36
Formula : C₁₉H₂₁FN₃O₅P
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM.Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. [1][2]
Reference:
[1] Oncogene 2012, 31, 251-264.
[2] Mol. Cancer Ther. 2007, 6, 845-956.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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