Apoptosis
MNK
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Product name : ZM 336372
Item : cc52
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 208260-29-1
Molecular Weight : 389.45
Formula : C₂₃H₂₃N₃O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM. ZM 336372 inhibits c-Raf by competing with ATP to bind to the protein. Alternate studies suggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β, GSK-3β through phosphorylation of GSK-3&beta at Ser 9. In addition, ZM-336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM336372 can also act as an agonist towards c-Raf, activating the MAPK pathway, which can be suppressed after activation by c-Raf itself, using a novel feedback loop in which activation is always followed by inactivation. [1][2]
Reference:
[1] Chem. Biol. 1999, 6, 559-568.
[2] Mol. Cancer Res. 2005, 4, 910-917.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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