Vemurafenib/Zelboraf/PLX4032/PLX-4032/PLX 4032/RG7204/RG-7204/RG 7204/RO5185426/RO-5185426/RO 5185426/acesobio supply

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Products > MAPK > Raf > PLX 4032 (RG 7204, Zelboraf, RO 5185426)

Product name : PLX 4032 (RG 7204, Zelboraf, RO 5185426)

Item : cc7

Price : 1g, $650;2g, $1050; 5g $1650

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CAS : 918504-65-1

Molecular Weight : 489.92

Formula : C₂₃H₁₈ClF₂N₃O₃S

Storage : at -20°C

Additional information : We offer significant discount for bulky quantity order

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Details:

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM. PLX-4032 selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers. ^[1][2]

Reference:

[1] Nature 2010,467, 596-599.

[2] Cancer Res. 2010, 70, 5518-5527.

Chemical Information

Molecular Weight (WM):	489.92
Formula:	C₂₃H₁₈ClF₂N₃O₃S
CAS No:	918504-65-1, 918505-61-0, 1029872-54-5
Purity:	≥ 98%
Synonyms:	RG-7204, RO-5185426
	DMSO ≥ 98 mg/mL
Solubility (25℃)	Water < 1 mg/mL
	Ethanol <1 mg/mL
	2 years -20℃ Powder
Stability:	2 weeks -4℃ in DMSO
	2 months -80℃ in DMSO