Apoptosis
DHFR
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Product name : CX 5461
Item : cc1
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1138549-36-6
Molecular Weight : 513.61
Formula : C₂₇H₂₇N₇O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX 5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts. [1][2]
Reference:
[1] Cancer Cell 2012, 22, 51-65.
[2] Cancer Res. 2011, 71, 1418-1430.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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