Apoptosis
VDAC
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Product name : EGT 1442
Item : cc285
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1118567-05-7
Molecular Weight : 464.94
Formula : C₂₄H₂₉ClO₇
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||
EGT1442 is a potent and selective SGLT2 inhibitor. The IC50 values for EGT-1442 against human SGLT1 and SGLT2 are 5.6μM and 2nM, respectively. Sodium glucose co-transporter 2 (SGLT2) is a renal type III integral membrane protein that co-transports sodium and glucose from filtrate to epithelium in the proximal tubule. Human subjects with homozygous or compound heterozygous mutations in SLC5A2 exhibit glucosuria without hypoglycemia or other obvious morbidity, suggesting that blockade of SGLT2 has the potential to promote normalization of blood glucose without hypoglycemia in the setting of type 2 diabetes. [1]
Reference:
[1] Pharmacol. Res. 2011, 63, 284-293.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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