Apoptosis
Btk
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Product name : PF 562271
Item : cc23
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 717907-75-0
Molecular Weight : 507.49
Formula : C₂₁H₂₀F₃N₇O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||||||||
PF-562271 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 catalytic activity with IC50 of 1.5 nM and 14 nM, respectively. And in cell-based assays, the IC50 of PF562271 is shown to be 5 nM for FAK, which is more selective compared to other kinase targets. In 2 dimensional (2D) cultures, PF-562271 results in a dose-dependent cell proliferation inhibition in FAK WT, FAK−/− and FAK kinase-deficient (KD) cells with IC50 of 3.3 μM, 2.08 μM and 2.01 μM, respectively. [1][2]
Reference:
[1] Cancer Res. 2008, 68, 1935-1944.
[2] Cancer Biol. Ther. 2010, 10, 38-43.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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