Product name : Nolatrexed (AG 337)
Item : cc289
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
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CAS : 152946-68-4
Molecular Weight : 357.26
Formula : C14H14Cl2N4OS
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displaying an IC50 of between 0.39 microM 6.6 microM. TS was suggested as the locus of action of AG-337 by the ability of thymidine to antagonize cell growth inhibition and the direct demonstration of TS inhibition in whole cells using a tritium release assay. [1][2]
Reference:
[1] Clin. Caner Res. 1995, 1, 1275-1284.
[2] Caner Chemother. Pharmacol. 1996, 37, 509-517.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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