Favorite  |  Set Home
Products > Cell Cycle > Synthase > Nolatrexed (AG 337)
Product name : Nolatrexed (AG 337)
Item : cc289
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 152946-68-4
Molecular Weight : 357.26
Formula : C14H14Cl2N4OS
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]             


Details:
Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displaying an IC50 of between 0.39 microM 6.6 microM. TS was suggested as the locus of action of AG-337 by the ability of thymidine to antagonize cell growth inhibition and the direct demonstration of TS inhibition in whole cells using a tritium release assay.  [1][2]
 
Reference:
[1] Clin. Caner Res. 1995, 1, 1275-1284.
[2] Caner Chemother. Pharmacol. 1996, 37, 509-517.
 
 
Chemical Information
Molecular Weight (WM):
357.258
Formula:
C14H14Cl2N4OS
CAS No:
152946-68-4, 147149-76-6
Purity:
≥ 98%
Synonyms:
AG337
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
Raltitrexed (Tomudex)
Raltitrexed (Tomudex)
Price: 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795