Apoptosis
DPP4
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Product name : Delanzomib (CEP 18770)
Item : cc287
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 847499-27-8
Molecular Weight : 413.28
Formula : C₂₁H₂₈BN₃O₅
Storage : C₂₃H₂₄N₆
Additional information : We offer significant discount for bulky quantity order
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Delanzomib (CEP-18770) is a potent chymotrypsin-like proteasome inhibitor with an IC50 of 3.8 nM.Delanzomib (CEP18770) represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. [1][2]
Reference:
[1] Blood 2008, 111, 2765-2775.
[2] Br. J Haematol. 2010, 148, 569-581.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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