Apoptosis
Sigma Receptor
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Product name : LDE 225 (Erismodegib)
Item : cc76
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1218778-77-8
Molecular Weight : 681.49
Formula : C₂₆H₃₂F₃N₃O₁₁P₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||||||||
LDE225 (NVP-LDE225, Erismodegib) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. Smo antagonist NVP-LDE225 inhibits Hh signaling and induces tumor regression in animal models of medulloblastoma. LDE-225 significantly reduced tumor volume by 95% compared with untreated control mice. Hedgehog inhibition with LDE225 significantly prolonged median survival in the used transgenic mouse model. [1][2]
Reference:
[1] Sci. Transl. Med. 2010, 2, 51a70.
[2] Ann. Surg. 2011, 254, 818-823.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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