Product name : VX 770 (Ivacaftor)
Item : cc231
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
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CAS : 873054-44-5
Molecular Weight : 392.49
Formula : C₂₄H₂₈N₂O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Ivacaftor (VX-770) is a CFTR potentiator with an IC50 of 43 ± 38 nM. In recombinant cells Ivacaftor (VX770) increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. Ivacaftor (VX 770) also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore,Ivacaftor (VX-770) reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures.Ivacaftor (VX-770) is useful for treatment of Cystic fibrosis. [1]
Reference:
[1] Proc. Natl. Acad. Sci. USA 2009, 106, 18825-18830.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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