Apoptosis
EGFR
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Product name : AZ 960
Item : cc210
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 905586-69-8
Molecular Weight : 354.36
Formula : C₁₈H₁₆F₂N₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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AZ-960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki and of <3 nM and 0.45 nM, respectively.AZ960 demonstrated selectivity for TEL-JAK2-driven STAT5 phosphorylation and cell proliferation when compared with cell lines driven by similar fusions of the other JAK kinase family members. In the SET-2 human megakaryoblastic cell line, heterozygous for the JAK2 V617F allele, inhibition of JAK2 resulted in decreased STAT3/5 phosphorylation and inhibition of cell proliferation (GI(50)=0.033 microm) predominately through the induction of mitochondrial-mediated apoptosis. [1][2]
Reference:
[1] J Biol. Chem. 2008, 283, 32334-32343.
[2] Mol. Cancer Ther. 2010, 9, 3386-3395.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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