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Products > Transmembrane Transporter > SGLT > Canagliflozin (JNJ 28431754)
Product name : Canagliflozin (JNJ 28431754)
Item : cc209
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 842133-18-0
Molecular Weight : 444.52
Formula : C₂₄H₂₅FO₅S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Canagliflozin (JNJ-28431754) is a highly potent and selective subtype 2 sodium-glucose transport protein (SGLT2) inhibitor for CHO- hSGLT2, CHO- rSGLT2 and CHO- mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.Canagliflozin lowers plasma glucose (PG) by lowering the renal threshold for glucose (RT(G) ) and increasing urinary glucose excretion (UGE).   [1][2]
 
Reference:
[1] J Med. Chem. 2010, 53, 6355-6360.
[2] Diabetes Obes. Metab. 2011, 13, 669-672.
 
 
Chemical Information
Molecular Weight (WM):
444.52
Formula:
C24H25FO5S
CAS No:
842133-18-0, 928672-86-0 (0.5H2O)
Purity:
≥ 98%
Synonyms:
JNJ28431754
 
DMSO ≥ 89 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 89 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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