Apoptosis
Telomerase
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Product name : AS 252424
Item : cc208
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 900515-16-4
Molecular Weight : 305.28
Formula : C₁₄H₈FNO₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. AS252424 inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. [1][2]
Reference:
[1] Nat. Rev. Drug Discov. 2005, 4, 988-1004.
[2] J Med. Chem. 2006, 49, 3857-3871.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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