Product name : PCI 32765
Item : cc214
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : We offer significant discount for bulky quantity order
Molecular Weight : 936563-96-1
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PCI-32765 (Ibrutinib) is a potent and highly selective Bruton's tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM. PCI32765 binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor (BCR) signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. [1][2]
Reference:
[1] Proc. Natl. Acad. Sci. USA 2010, 107, 13075-13080.
[2] Blood 2011, 117, 6287-6296.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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