Product name : LY 2157299
Item : cc8
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 700874-72-2
Molecular Weight : 369.42
Formula : C₂₂H₁₉N₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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LY2157299 is a potent TβRI and TβRII (transforming growth factor β receptor I and II) inhibitor with IC50 of 86 nM and 2 nM, respectively. In human glioblastoma (GBM) cells, LY-2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD.Most importantly, treatment with LY 2157299 stimulated hematopoiesis from primary MDS bone marrow specimens. [1][2]
Reference:
[1] Cancer Res. 2011, 71, 955-963.
[2] Eur. J Cancer 2008, 44, 142-150.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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