Apoptosis
TGF-β Receptor
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Product name : LY2109761
Item : cc120
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 700874-71-1
Molecular Weight : 441.52
Formula : C₂₆H₂₇N₅O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||||||||
LY2109761 is a novel selective TGFβ receptor type I and type II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively. Blocking TβRI/II kinase activity with LY-2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY 2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression. [1][2]
Reference:
[1] Mol. Cancer Ther. 2008, 7, 829-840.
[2] Hepatology 2008, 47, 1557-1566.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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