Apoptosis
Aurora Kinase
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Product name : SNS 032 (BMS 387032)
Item : cc229
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 345627-80-7
Molecular Weight : 380.53
Formula : C₁₇H₂₄N₄O₂S₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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SNS-032 (BMS387032) is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. CDK inhibitor SNS032 (BMS-387032)selectively binds to CDKs 2, 7, and 9, preventing their phosphorylation and activation; inhibition of CDK activity may result in cell cycle arrest, the induction of apoptosis and decreased tumor cell proliferation in susceptible tumor cell populations. This agent has been shown to sensitize radioresistant tumor cells to ionizing radiation. [1][2]
Reference:
[1] Blood 2009, 113, 4637-4645.
[2] Neoplasia 2007, 9, 370-381.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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