Apoptosis
Serotonin Transporter
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Product name : DAPT (GSX-IX)
Item : cc201
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 208255-80-5
Molecular Weight : 432.46
Formula : C₂₃H₂₆F₂N₂O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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DAPT (GSX-IX) is a novel inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT does not effect APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. [1][2]
Reference:
[1] J Neurochem. 2001, 76, 173-181.
[2] Neuroscience 2012, 210, 99-109.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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