Apoptosis
MNK
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Product name : GSK 1120212 (Trametinib, JPT 74)
Item : cc-37
Price : 2g, $750;5g, $1250; 10g $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 871700-17-3
Molecular Weight : 615.39
Formula : C₂₆H₂₃FIN₅O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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GSK 1120212 (Tranmetinib) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 nM and 0.9 nM for MEK1 and MEK2. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. [1][2]
Reference:
[1] Int. J Oncol. 2011, 39, 23-32.
[2] Curr. Oncol. Rep. 2010, 12, 146-152.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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