Apoptosis
Isocitrate dehydrogenase
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Product name : TH 302
Item : cc588
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 918633-87-1
Molecular Weight : 449.04
Formula : C₉H₁₆Br₂N₅O₄P
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. [1][2]
Reference:
[1] J Med. Chem. 2008, 51, 2412-2420.
[2] Mol. Cancer Ther. 2012, 11, 740-741.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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