Apoptosis
Isocitrate dehydrogenase
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Product name : Orteronel (Synonyms: TAK-700)
Item : cc589
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 566939-85-3
Molecular Weight : 307.35
Formula : C₁₈H₁₇N₃O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively. TAK700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. [1][2]
Reference:
[1] J Steroid Biochem. Mol. Biol. 2012, 129, 115-128.
[2] Bioorg. Med. Chem. 2011, 19, 6383-6399.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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