Product name : Etravirine (TMC 125)
Item : cc89
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 269055-15-4
Molecular Weight : 435.28
Formula : C₂₀H₁₅BrN₆O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Etravirine (TMC-125) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine. This potency appears to be related to etravirine's flexibility as a molecule. Etravirine is a diarylpyrimidine (DAPY), a type of organic molecule with some conformational isomerism that can bind the enzyme reverse transcriptase in multiple conformations, allowing for a more robust interaction between etravirine and the enzyme, even in the presence of mutations. [1][2]
Reference:
[1] Eur. J Med. Res. 2007, 12, 483-495.
[2] J Med. Chem. 2004, 47, 2550-2560.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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