Favorite  |  Set Home
Products > MAPK > Raf > SB 590885
Product name : SB 590885
Item : cc-3
Price : 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 405554-55-4
Molecular Weight : 453.54
Formula : C₂₇H₂₇N₅O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
SB 590885 is an orally bioavailable inhibitor of B-raf (BRAF) protein with a Ki app of 0.16 ± 0.03 nM. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. [1]
 
Reference:
[1] Cancer Res. 2006, 66, 11100-11105.
                                        
Chemical Information
Molecular Weight (WM):
453.54
Formula:
C27H27N5O2
CAS No:
405554-55-4
Purity:
≥ 98%
Synonyms:
GSK-2188436, GSK2188436, SB590885
 
DMSO ≥ 16 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

Related Products :
ZM 336372
ZM 336372
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
Dabrafenib (GSK 2118436)
Dabrafenib (GSK 2118436)
Price: 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Price: 1g, $650;2g, $1050; 5g $1650
NVP-BHG712
NVP-BHG712
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
GDC 0879
GDC 0879
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
LGX-818
LGX-818
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
Sorafenib (Nexavar)
Sorafenib (Nexavar)
Price: 2g, $650;5g, $1050; 10g $1650
AZ 628
AZ 628
Price: 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450