Product name : Lonafarnib (SCH 66336)
Item : cc590
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 193275-84-2
Molecular Weight : 638.82
Formula : C₂₇H₃₁Br₂ClN₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Lonafarnib (SCH66336) is a selectively farnesyl protein transferase (FPT) inhibitor of H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonarfanib (SCH-66336) binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. [1][2]
Reference:
[1] Cancer Res. 1998, 58, 4947-4956.
[2] Cancer Res. 2003, 63, 4796-4800.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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