Apoptosis
Aurora Kinase
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Product name : PD 0332991
Item : cc424
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 571190-30-2
Molecular Weight : 447.53
Formula : C₂₄H₂₉N₇O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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PD0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. [1][2]
Reference:
[1] Mol. Cancer Ther. 2004, 3, 1427-1438.
[2] Cancer Res. 2008, 68, 5519-5523.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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