Apoptosis
MAO
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Product name : Bexarotene
Item : cc197
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 153559-49-0
Molecular Weight : 348.48
Formula : C₂₄H₂₈O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Bexarotene is a retinoid specifically selective for retinoid X receptors, as opposed to the retinoic acid receptors. RXRs are located primarily in visceral organs such as the liver and kidney. Activated RXRs form homodimers or heterodimers with retinoic acid receptors, vitamin D receptors, thyroid receptors or peroxisome proliferator-activated receptors. Once activated, these retinoid receptor dimers bind to DNA at retinoic acid response elements and act as transcription factors that regulate the expression of genes which control cellular differentiation and proliferation. Retinoid agonists can activate the expression of retinoid regulated genes by removing negative transcription control or by facilitating positive transcriptional activity. They exert anticancer action by interfering with the growth of cells of the tumor. [1][2]
Reference:
[1] Br. J Dermatol. 2007, 157, 433-440.
[2] Clin. Cancer Res. 2007, 13, 1794-1800.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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